Good News In Our DNA!


Good News In Our DNA: Defects You Can Fix With
Vitamins And Minerals
ScienceDaily (Jun. 3, 2008) — As the cost of sequencing a single
human genome drops rapidly, with one company predicting a price
of $100 per person in five years, soon the only reason not to look
at your “personal genome” will be fear of what bad news lies in
your genes.
University of California, Berkeley, scientists, however, have found
a welcome reason to delve into your genetic heritage: to find the
slight genetic flaws that can be fixed with remedies as simple as
vitamin or mineral supplements.
“I’m looking for the good news in the human genome,” said Jasper
Rine, UC Berkeley professor of molecular and cell biology.
“Headlines for the last 20 years have really been about the triumph
of biomedical research in finding disease genes, which is
biologically interesting, genetically important and frightening to
people who get this information,” Rine said. “I became obsessed
with trying to decide if there is some other class of information that
will make people want to look at their genome sequence.”
What Rine and colleagues found and report in the online early
edition of the journal Proceedings of the National Academy of
Sciences (PNAS) is that there are many genetic differences that
make people’s enzymes less efficient than normal, and that simple supplementation with vitamins can often restore
some of these deficient enzymes to full working order.
First author Nicholas Marini, a UC Berkeley research scientist, noted that physicians prescribe vitamins to “cure”
many rare and potentially fatal metabolic defects caused by mutations in critical enzymes. But those affected by these
metabolic diseases are people with two bad copies, or alleles, of an essential enzyme. Many others may be walking
around with only one bad gene, or two copies of slightly defective genes, throwing their enzyme levels off slightly
and causing subtle effects that also could be eliminated with vitamin supplements.
“Our studies have convinced us that there is a lot of variation in the population in these enzymes, and a lot of it affects
function, and a lot of it is responsive to vitamins,” Marini said. “I wouldn’t be surprised if everybody is going to
require a different optimal dose of vitamins based on their genetic makeup, based upon the kind of variance they are
harboring in vitamin-dependent enzymes.”
Though this initial study tested the function of human gene variants by transplanting them into yeast cells, where the
function of the variants can be accurately assessed, Rine and Marini are confident the results will hold up in humans.
Their research, partially supported by the Defense Advanced Research Projects Agency (DARPA) and the U.S.
Army, may enable them to employ U.S. soldiers to test the theory that vitamin supplementation can tune up defective
enzymes.
“Our soldiers, like top athletes, operate under extreme conditions that may well be limited by their physiology,” Rine
said. “We’re now working with the defense department to identify variants of enzymes that are remediable, and
ultimately hope to identify troops that have these variants and test whether performance can be enhanced by
appropriate supplementation

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About thelifestylechanger

Glenda De Luca has spent over 25 years in the Beauty Industry, and has transitioned from the temporary beauty fix to permanent health and well-being, helping others transform their outer beauty based on nutrition and movement. She has also spent two years doing extensive research on the effects of pH levels in the body, and its profound impact on your health and well being. THE LIFESTYLE CHANGER Orange County, CA, USA 949.215.5701 Office 408.398.8043 Cell E-mail: thelifestylechanger@live.com Glenda has a Bachelor of Science degree in Para Psychic Sciences as well as a Level 2 Reiki Certification and is currently studying for her Masters in Holistic Nutrition. She lives a healthy lifestyle where she incorporates what she loves to eat based on a pH balanced diet, food combining, and customized supplementation based on her own personal DNA. She also incorporates movement into her Lifestyle to achieve the perfect weight and health. She is passionate about helping others achieve their Health and Wellness "Desired Results" in a manner that is fun, easy and sustainable.
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